PSEUDO-TEMPORAL DYNAMICS OF CHEMORESISTANT TRIPLE NEGATIVE BREAST CANCER CELLS REVEAL EGFR/HER2 INHIBITION AS SYNTHETIC LETHAL DURING MID-NEOADJUVANT CHEMOTHERAPY

Summary: In the absence of targetable hormonal axes, chemoresistance for triple-negative Tail bags breast cancer (TNBC) often compromises patient outcomes.To investigate the underlying tumor dynamics, we performed trajectory analysis on the single-nuclei RNA-seq (snRNA-seq) of chemoresistant tumor clones during neoadjuvant chemotherapy (NAC).It rev

The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality.The clinical outcome of infection with Leishmania parasites depends on a variety of factors such as parasite spe

In the paper, the influence of modified Angren kaolin on the properties of composite elastomeric Tail bags materials based on butadiene-styrene rubber has been established that the addition of modified Angren kaolin into rubber mixtures instead of gas pedals, activators and mineral fillers causes intensive connection of sulfur with macromolecules.A

Unmanned Aerial Vehicles (UAVs), commonly known as drones, are increasingly being employed across a Shatavari broad spectrum of applications, ranging from military operations to commercial purposes.However, as UAVs become more integrated into everyday life, security and privacy concerns are similarly escalating due to vulnerabilities arising from o

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), VEGETABLE JUICE and SERPINA6 mRNA expression encoding corticosteroid-binding globulin (CBG) in the liver.Th